Biomedical Optics: Principles and Imaging This entry-level textbook, covering the area of tissue optics, is based on the lecture notes for a. This entry-level textbook, covering the area of tissue optics, is based on the lecture notes for a graduate course (Bio-optical Imaging) that has been taught six . Lihong Wang and Hsin-I Wu, professors of biomedical engineering with outstanding teaching and research experience, faced a common dilemma: the lack of an.
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Biomedical Imaging using Optical Coherence Tomography 8. Two-Photon . light and tissues, the principles of spectroscopy, the design of. PDF | David A. Boas, Constantinos Pitris, and Nimmi Ramanujam, Eds.: Handbook of Biomedical Optics The publication of Handbook of Biomedical Optics co uld, in my view, be considered a .. Biomedical Optics: Principles and Imaging. What is Biomedical Optics? • A consideration of the Optical imaging instruments tend to work in either the. “single scattering” .. Can use principles of diffuse optical tomography to gain 3D images. • Easier in mice . Jacques_PMBpdf.
These types of light generate images by exciting electrons without causing the damage that can occur with ionizing radiation used in some other imaging techniques. Because it is much safer for patients, and significantly faster, optical imaging can be used for lengthy and repeated procedures over time to monitor the progression of disease or the results of treatment.
Optical imaging is particularly useful for visualizing soft tissues. Soft tissues can be easily distinguished from one another due to the wide variety of ways different tissues absorb and scatter light.
Because it can obtain images of structures across a wide range of sizes and types, optical imaging can be combined with other imaging techniques, such as MRI or x-rays, to provide enhanced information for doctors monitoring complex diseases or researchers working on intricate experiments. Optical imaging takes advantage of the various colors of light in order to see and measure many different properties of an organ or tissue at the same time.
Other imaging techniques are limited to just one or two measurements. What types of optical imaging are there and what are they used for?
Multiphoton microscopy of amyloid deposits in mouse model of Alzheimer's Disease.
Source: M. Garcia-Alloza, Massachusetts General Hospital Optical imaging includes a variety of techniques that use light to obtain images from inside the body, tissues or cells. Endoscopy: The simplest and most widely recognized type of optical imaging is endoscopy. An endoscope consists of a flexible tube with a system to deliver light to illuminate an organ or tissue.
Optical Coherence Tomography OCT : Optical coherence tomography is a technique for obtaining sub-surface images such as diseased tissue just below the skin. OCT is a well-developed technology with commercially available systems now in use in a variety of applications, including art conservation and diagnostic medicine.
For example, ophthalmologists use OCT to obtain detailed images from within the retina. Cardiologists also use it to help diagnose coronary artery disease. The technique can be used for a number of clinical applications including monitoring blood vessel growth in tumors, detecting skin melanomas, and tracking blood oxygenation in tissues.
A laser that uses near-infrared light is positioned on the scalp. The light goes through the scalp and harmlessly traverses the brain. The absorption of light reveals information about chemical concentrations in the brain. The scattering of the light reflects physiological characteristics such as the swelling of a neuron upon activation to pass on a neural signal.
Raman Spectroscopy: This technique relies on what is known as Raman scattering of visible, near-infrared, or near-ultraviolet light that is delivered by a laser. The laser light interacts with molecular vibrations in the material being examined, and shifts in energy are measured that reveal information about the properties of the material. The technique has a wide variety of applications including identifying chemical compounds and characterizing the structure of materials and crystals.
In medicine, Raman gas analyzers are used to monitor anesthetic gas mixtures during surgery. Back Scattering interferometry for molecular imaging. Summary of MCML. Probability density function. General formulation of convolution. Convolution over a Gaussian beam.
Convolution over a top-hat beam. Numerical solution to convolution. Appendix 4. Summary of CONV. Definitions of physical quantities.
Derivation of the radiative transport equation. Diffusion theory. Boundary conditions. Diffuse reflectance. Photon propagation regimes. Hybrid model. Numerical computation. Collimated transmission method. Oblique-incidence reflectometry.
White-light spectroscopy. Time-resolved measurement. Fluorescence spectroscopy. Fluorescence modeling. Characteristics of ballistic light. Time-gated imaging. Spatial-frequency filtered imaging. Polarization-difference imaging. Coherence-gated holographic imaging. Optical heterodyne imaging. Radon transformation and computed tomography. Confocal microscopy.
Two-photon microscopy. Appendix 8. Michelson interferometry. Coherence length and coherence time. Time-domain OCT. Fourier-domain rapid scanning optical delay line.
Fourier-domain OCT. Doppler OCT. Group velocity dispersion.
Monte Carlo modeling of OCT. Mueller calculus versus Jones calculus. Polarization state. Stokes vector. Mueller matrix.
Mueller matrices for a rotator, a polarizer, and a retarder. Measurement of Mueller matrix. Jones vector. Jones matrix. Jones matrices for a rotator, a polarizer, and a retarder. Eigenvectors and eigenvalues of Jones matrix. Conversion from Jones calculus to Mueller calculus.
Degree of polarization in OCT. Serial Mueller OCT. Parallel Mueller OCT. Modes of diffuse optical tomography. Time-domain system.
Direct-current system. Frequency-domain system. Frequency-domain theory: Appendix Motivation for photoacoustic tomography. Initial photoacoustic pressure.
General photoacoustic equation.